en تخصصي Special پژوهشي Research paper This paper establishes a study on some important latest innovations in the uniqueness of solution for Caputo fractional Volterra-Fredholm integro-differential equations. To apply this, the study uses Banach contraction  principle and Bihari's inequality.  A wider applicability of these techniques are based on their reliability and reduction in the size of the mathematical work. Caputo fractional derivative, Volterra-Fredholm integro-differential equation, Banach contraction principle, Bihari’s inequality. 135 144 http://ijmsi.ir/browse.php?a_code=A-10-3687-1&slc_lang=en&sid=1 A. Hamoud drahmed985@yahoo.com 10031947532846009224 10031947532846009224 Yes Department of Mathematics, Taiz University, Taiz, Yemen K. Ghadle drkpghadle1974@gmail.com 10031947532846009225 10031947532846009225 No Department of Mathematics, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India